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M9490551.TXT
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1994-09-24
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Document 0551
DOCN M9490551
TI [Bone sterilization by radiation and the HIV virus]
DT 9411
AU Hernigou P; Marce D; Julieron A; Marinello G; Dormont D; Chirurgie
Orthopedique, Hopital Henri Mondor, Creteil.
SO Rev Chir Orthop Reparatrice Appar Mot. 1993;79(6):445-51. Unique
Identifier : AIDSLINE MED/94345209
AB An experimental study was performed to investigate the efficacy of
irradiating HIV-contaminated allografts. Irradiation was achieved using
an accelerator delivering 6.3 MeV electrons, and the viral strain was
HIV-1/LAV-1. At an activity equivalent to 600.000 counts of reverse
transcriptase activity per minute and per millilitre, irradiation
permitted total inactivation of HIV. In the light of present data
concerning plasma viremia in HIV-infected patients, this experiment
suggested that irradiation minimizes as far as possible the risk of
transmitting HIV infection through bone transplantation from a
seronegative, contaminant donor. However, in view of the relative
imprecision of viral sensitivity curves, irradiation does not authorize
bone transplantation from a seropositive patient, even though the bone
has been irradiated.
DE Animal Bone Marrow Transplantation *Bone Transplantation Cells,
Cultured Dose-Response Relationship, Radiation English Abstract Human
HIV Infections/*PREVENTION & CONTROL/TRANSMISSION
HIV-1/PATHOGENICITY/*RADIATION EFFECTS Lymphocytes/MICROBIOLOGY
Radiotherapy, High-Energy/*METHODS Sterilization/*METHODS
Virulence/RADIATION EFFECTS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).